Specificity of lytic factors for erythrocytes, leukocytes and platelets in a case of pancytopenia.

(‘Oflsbinsed cytopensias, ins which nsore than one blood cell type is affected its the sanse individual, are of imsterest.. Ats anstileukocyte factor has recenutly heems demonust.rated ins sonse cases of pancyt.openia. Ins the case of IKissnuseyer-Nielsen6 and in that of Moeschlins7 the evidence vas derived from transfusions experimenits. Dausset8 usinsg the ins vitro agglutimsations metho.d founsd leukoagglutinatinsg activity in 48 sera. Of these, 8 sera constaimsed anstibodies for another cell type, either erythrocytes 0)1 platelets, whereas anst.ihodies for all three cell types were found ins 3 sera. In a case of paiscytopensia, reported briefly ins the presenst conusnssunieationi, inscreased destructions of all three blood cell elemenuts was densomsst.rated in vivo. In addition, the antileukocyte anud anstiplatelet factors involved s ’ere show’ns by ins Vitro issethods to he aggluntinsimus. This case afforded ans opportunniity to stundy the problens : is increased destrunctions of sore thans onse blood cell elenssemst. in the saisse insdividusal due to) a siisgle (or t.o multiple) cell-type specific factors?